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Communication | Regular issue | Vol 36, No. 12, 1993, pp.2663-2667
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6506
Formation of Novel Isoxazoline Spiro Compounds by a Reaction of Aryl Substituted α-Nitroacrylates with Titanium Tetrachloride and Toluene

Seiko Hirotani* and Shonosuke Zen

*School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku, Tokyo 108-8641, Japan


New spiroisoxazoline derivatives were synthesized via novel cyclization of arylsubstituted α-nitroacrylates (naphthyl and phenanthryl analogues) with TiCl4 and toluene. The structural determination by single crystal X-ray analysis is reported.