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Communication | Regular issue | Vol 38, No. 1, 1994, pp.1-4
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6467
Radical Cyclization of 1-Benzylisoquinoline-3-ones: A New Synthesis of the 4,5-Dioxoaporphine Pontevedrine

Juan C. Estévez, M. Carmen Villaverde, Ramón J. Estévez, and Luis Castedo*

*Departamento de Química Orgánica Universidad de Santiago, Secciòn de Alcaoids (C.S.I.C), E-15706, Santiago de Compostela, Spain

Abstract

Tributyltin hydride induced intramolecular radical cyclization of 1-bromobenzylisoquinoline-3-one (1) allowed us to obtain the new 5-oxoaporphines (4 and 5), which were converted into the 4,5-dioxoaporphine pontevedrine (3b).