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Paper | Regular issue | Vol 36, No. 10, 1993, pp.2327-2333
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6450
Synthesis and Serotonergic Activity of 8-[4-(2,3-Dihydro-1,4-dioxino[2,3-b]pyridin-2-yl-methylamino)butyl]-8-azaspiro[4,5]decane-7,9-dione

Abdelhakim Benarab and Gerald Guillaumet*

*Laboratoire de Chimie Bioorganique et Analytique, URA-CNRS N° 499, Université d’Orléans, BP 6759, Rue de Chartres, 45067 Orleans Cedex 2, France


The synthesis of compound (9), a nitrogen-containing bioisostere of the 1,4-benzodioxane moiety of the MDL 72832, is detailed. This compound showed a moderate affinity for the 5-HT1A receptors.