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Communication | Regular issue | Vol 36, No. 9, 1993, pp.1971-1974
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6441
N-Demthylation Studies of Pavine Alkaloids

Shoei-Sheng Lee,* Yi-Chu Liu, Shu-Hwei Chang, and Chung-Hsiung Chen

*School of Pharmacy, National Taiwan University, 1, Jen-Ai Road, Section 1, Taipei 10018, Taiwan, R.O.C.


The N-norpavines, ring homologues of MK-801— a potent NMDA receptor antagonist, were prepared from N-methyl quaternary pavines by two nucleophilic reaction steps: N-methyl quaternary ammonium salts into tertiary amine by reacting with NaHTe (ethanolamine/δ or OAc- salt/DMF, δ); tertiary amine into N-norpavines by the von Braun reaction and subsequent hydrolysis.