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Paper | Regular issue | Vol 36, No. 10, 1993, pp.2273-2280
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6412
Synthesis of 4-Amino-8-cyanoquinazolines from Enones and Enals

Pedro J. Victory,* José I. Borrell, Anton Vidal-Ferran, Elvira Montenegro, and M. Luisa Jimeno

*Departament de Química Organica, CETS Institut Químic de Sarria, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain

Abstract

The treatement in a sodium methoxide/methanol solution of α,β-unsaturated enones or aldehydes with propanedinitrile in a 1:2 molar ratio led to 2-aminobenzene-1,3-dicarbonitriles. These compounds afforded 4-amino-8-cyanoquinazolines by reaction with formamide or guanidine.