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Paper | Regular issue | Vol 36, No. 8, 1993, pp.1859-1866
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6391
Nucleophilic Substitution Reaction of 1-Hydroxytryptophan and 1-Hydroxytryptamine Derivatives (Regioselective Syntheses of 5-Substituted Derivatives of Tryptophane and Tryptamine)

Masanori Somei* and Yoshikazu Fukui

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


Regioselective nucleophilic substitution at the 5-position of indole nucleus was observed in the reaction of 1-hydroxytryptophan and 1-hydroxytryptamine derivatives with acids, suggesting the mechanism of serotonin formation in the central nervous system.