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Communication | Regular issue | Vol 36, No. 10, 1993, pp.2185-2190
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6387
Synthesis of Highly Substituted Pyridines through Nucleophilic Substitution of Tetrachloro-3-cyanopyridine

Sergei V. Chapyshev and Toshikazu Ibata*

*Institute of Chemistry, College of General Educatin, Osaka University, Toyonaka, Osaka 560-8531, Japan

Abstract

Tetrachloro-3-cyanopyridine reacts with anilines and/or sodium azide through replacement of three chlorine atoms at the 2-, 4-, and 6-positions, whereas with difunctional nucleophiles by replacement of chlorines at the 5- and 6-positions. Using these reactions synthesis of highly substituted pyridines has been developed.