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Paper | Regular issue | Vol 36, No. 8, 1993, pp.1823-1836
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6372
Synthesis of (+)-Preussin

Makoto Shimazaki, Fumiaki Okazaki, Fumihiro Nakajima, Tetsuya Ishikawa, and Akihiro Ohta*

*Tokyo College of Pharmacy , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

A total synthesis of (+)-preussin (1), a novel antifungal agent, was achieved via asymmetric 1,3-dipolar cycloaddition of decyl methyl nitrone (2) with (-)-1-phenyl-3-buten-2-ol (3) as a key reaction.