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Paper | Regular issue | Vol 36, No. 6, 1993, pp.1387-1398
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6341
A Friedländer Approach to 3-Substituted 2,5,8-(1H)-Quinolinetriones

Ma del Mar Blanco, Carmen Avendaño,* Nieves Cabezas, and J. Carlos Menédez

*Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain


An efficient method is proposed for the preparation of 3-substituted carbostyrilquinone derivatives, based on Friedländer synthesis of the 5,8-dialkoxyquinolines followed by cerium ammonium nitrate oxidative demethylation.