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Communication | Special issue | Vol 35, No. 1, 1993, pp.143-146
Published online, 1st January, 1970
DOI: 10.3987/COM-92-S61
A Synthetic Approach to the Marine Sponge Alkaloids Agelasimine A and Agelasimine B

Tohru Saito, Jun Chikazawa, Yuko Nakamura, and Tozo Fujii*

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


Syntheses of 7-benzyl-N6,3-dimethyladenine (1b) and 7-benzyl-1,2-dihydro-1,3-dimethyladenine (2b), selected as models for the marine sponge alkaloids agelasimine A (1a) and agelasimine B (2a), respectively, have been achieved via four-step routes starting from 3-methyladenine (7). The key steps involved are regioselective methylations of 7-benzyl-3-methyladenine (9) and 7-benzyl-1,2-dihydro-3-methyladenine (11).