Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 35, No. 1, 1993, pp.143-146
Published online, 1st January, 1970
DOI: 10.3987/COM-92-S61
A Synthetic Approach to the Marine Sponge Alkaloids Agelasimine A and Agelasimine B

Tohru Saito, Jun Chikazawa, Yuko Nakamura, and Tozo Fujii*

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

Syntheses of 7-benzyl-N6,3-dimethyladenine (1b) and 7-benzyl-1,2-dihydro-1,3-dimethyladenine (2b), selected as models for the marine sponge alkaloids agelasimine A (1a) and agelasimine B (2a), respectively, have been achieved via four-step routes starting from 3-methyladenine (7). The key steps involved are regioselective methylations of 7-benzyl-3-methyladenine (9) and 7-benzyl-1,2-dihydro-3-methyladenine (11).