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Paper | Regular issue | Vol 36, No. 6, 1993, pp.1337-1349
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6316
Synthesis of Pyrazino[1,2-a:4,5-a’]di[1,8]naphthyridine and Pyrazino[1,2-a][1,8]naphthyridines

Vicente Ojea and José Ma Quintela*

*Departamento de Química Fundamentale Industrial, Facultad de Ciencias, Universidad de La Coruña, Campus de A Zapateria, s/n, E-15071, La Coruña, Spain


A series of 3-alkyl-, 3-aryl- and 3-hetarylhexahydro-1H-pyrazino[1,2-a][1,8]naphthyridines (4) were prepared from 2-(4-substituted 1-piperazinyl)-3-formylpyridines (2) by condensation with malononitrile and subsequent thermal cyclization. Octahydro[1,2-a:4,5-a’]di[1,8]naphthyridine (7) was also obtained.