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Paper | Regular issue | Vol 36, No. 6, 1993, pp.1323-1332
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6306
Nucleophilic Substitution Reactions on Chlorinated Thiophene Derivatives as Basis for the Synthesis of Thienoanellated O,N- and S,N-Heterocycles

Isolde Puschmann and Thomas Erker*

*Institute of Pharmaceutical Chemistry, University of Vienna, Währinger Strasse 10, A-1090 Vienna, Austria


The reactivity of 5-acetyl-2-chloro-3-nitrothiophene with amines, alcohols, thiols and bifunctional compounds, as well as reactions of methyl 5-chloro-4-nitro-2-thiophenecarboxylate with various hydrazides are described. These substitution reactions provide an easy access to thienoanellated heterocycles.