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Paper | Regular issue | Vol 36, No. 5, 1993, pp.1091-1103
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6285
Studies on 1,2,4-Benzothiadiazine 1,1-Dioxides VII and Quinazolinones IV: Synthesis of Novel Built-In Hydroxyguanidine Tricycles as Potential Anticancer Agents

Ji-Wang Chern,* Yen-Chywan Liaw, Chien-Shu Chen, Jiann-Gwo Rong, Chien-Lin Huang, Chao-Han Chan, and Andrew H.-J. Wang

*Institute of Pharmacy and Medical Laboratories, National Defense Medical Center, P.O. Box 90048-512, Taipei, Taiwan, R.O.C.


Two representative built-in hydroxyguanidine tricycles containing 1,2,4-benzothiadiazine 1,1-dioxides (3) and quinazolinones (4) were prepared by reductive cycliazation of 1-(2-nitrophenylsulfonyl)-2-benzylthio-2-imidazoline (9a), 1-(2-nitrophenylsulfonyl)-2-benzylthio-1,4,5,6-tetrahydropyrimidine (9b), 1-(2-nitrobenzoyl)-2-benzylthio-2-imidazolidine (10a) and 1-(2-nitrobenzoyl)-2-benzylthio-1,4,5,6-tetrahydropyrimidine hydrobromide respectively (10b) with zinc dust in acetic acid under ice-cooling. 2,10-Dihydro-10-hydroxy-3H-imidazo[1,2-b][1,2,4]benzothiadiazine 5,5-dioxide (3a) and 2,3,4,11-tetrahydro-11-hydroxypyrimido[1,2-b][1,2,4]benzothiadiazine 6,6-dioxide (3b) were found to be active against solid tumor cell lines such as KB, Colo 205, HeLa, and Hepa-2.