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Communication | Regular issue | Vol 36, No. 3, 1993, pp.431-434
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6235
Preparation of New 2-Chloro-5-fluoro-6-(4-phenylmethylpiperazinyl)-4-trifluoromethyl-3-nicotinic Acid

Philippe Remuzon,* Daniel Bouzard, and Jean-Pierre Jacquet

*Bristol-Myers Squibb Pharmaceutical Research Institute, Lognes, BP 62, 77422 Marne-La-Vallée Cedex 2, France


The nicotinic acid (15), which could be a key intermediate for novel potential antibacterial 1,8-naphthyridine-3-carboxylic acid analogues, was prepared initiating with construction of the pyridine nucleus by ethyl 2-fluoroacetate and ethyl 2-trifluoroacetate.