Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 36, No. 4, 1993, pp.761-768
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6221
Chemical Modification of Erythromycins. X. Removal of Benzyloxycarbonyl and 2-Chlorobenzyl Groups of Erythromycin Derivatives by Use of Catalytic Transfer Hydrogenation

Yoshiaki Watanabe,* Masato Kashimura, Toshifumi Asaka, Takashi Adachi, and Shigeo Morimoto

*Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-Cho, Ohmiya, Saitama 330-8530, Japan


The benzyloxycarbonyl and the 2-chlorobenzyl groups of ethythromycin derivatives were easily removed by catalytic transfer hydrogenation (CTH). Their deprotection reaction was dependent on both the hydrogen donor and the solvent for use. Application of CTH to removal of the protective groups is discussed.