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Paper | Regular issue | Vol 36, No. 4, 1993, pp.733-742
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6207
A Convenient Synthesis of 5-Substituted Tetrahydro-1,4,3-oxathiazine 4,4-Dioxides

Evelyne Grunder-Klotz,* Paul Humbert, and Jean-Daniel Ehrhardt

*Laboratoire de Pharmacologie Cardiovasculaire et Rénale, URA 589 CNRS, Université Louis Pasteur, 11 rue Humann, F-67000 Strasbourg, France


An advantageous one pot procedure for the synthesis of tetrahydro-1,4,3-oxathiazine 4,4-dioxides by dialkylation of readily available α,N-alkyl- or arylsulfonamide dianions with gaseous formaldehyde is reported. Stability and some reactions of these heterocycles are also described.