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Paper | Regular issue | Vol 36, No. 1, 1993, pp.145-148
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6195
Convenient and Practical Synthesis of 5-Chloro-4-hydroxy-2(1H)-pyridinone

Shin-go Yano, Tomoyasu Ohno, and Kazuo Ogawa*

*Hanno Research Center, Taiho Pharmaceutical Co. Ltd., 1-27 Misugidai, Hanno, Saitama 357-0041, Japan


5-Chloro-4-hydroxy-2(1H)-pyridinone (1) was prepared by 4-step reactions via the key intermediate 5-chloro-3-cyano-4-methoxy-2(1H)-pyridinone (5). This synthetic route has several advantages over the reported methods in procedure, yield and applicability.