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Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Paper | Regular issue | Vol 36, No. 1, 1993, pp.145-148
Published online, 1st January, 1970■ Convenient and Practical Synthesis of 5-Chloro-4-hydroxy-2(1H)-pyridinone
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6195
■ Convenient and Practical Synthesis of 5-Chloro-4-hydroxy-2(1H)-pyridinone
Shin-go Yano, Tomoyasu Ohno, and Kazuo Ogawa*
*Hanno Research Center, Taiho Pharmaceutical Co. Ltd., 1-27 Misugidai, Hanno, Saitama 357-0041, Japan
Abstract
5-Chloro-4-hydroxy-2(1H)-pyridinone (1) was prepared by 4-step reactions via the key intermediate 5-chloro-3-cyano-4-methoxy-2(1H)-pyridinone (5). This synthetic route has several advantages over the reported methods in procedure, yield and applicability.
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