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Paper | Regular issue | Vol 36, No. 6, 1993, pp.1239-1251
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6170
Synthesis and Characterization of a Series of 5H-Benzo[a]phenoxazin-5-one Derivatives as Potential Antiviral/Antitumor Agents

Kanti G. Bhansali* and Alan M. Kook

*College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas 77251, U.S.A.

Abstract

A series of 1,2-benzo-3-phenoxazone also known as 5H-benzo[a]phenoxazin-5-one (1a-1c) were synthesized and characterized by 1- and 2-D nmr, mass spectrometry and computer simulation on readily available, inexpensive software. It is proposed that these molecules intercalated in GC rich DNA regions and that internal hydrogen bonding caused by a molecule of water in the salt will help to anchor these actinomycin D-like antibiotic into these locations.