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Paper | Regular issue | Vol 36, No. 1, 1993, pp.87-99
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6166
8H-Pyrazolo[5’,1’:2,3]pyrimido[5,4-d][1,2]diazepine: A New Tricyclic System

Fabrizio Bruni,* Barbara Cosimelli, Annarella Costanzo, Gabriella Guerrini, and Silvia Selleri

*Università di Firenze, Dipartimento di Scienze Farmaceutiche, Via Gino Capponi 9, I-50121 Firenze, Italy


Starting from a series of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines (2a-g), several derivatives of the pyrazolo[5’,1’: 2,3]pyrimido[5,4-a][1,2]diazepine system (3a-g) were obtained by reaction with hydrazine hydrate. Some compounds were finally alkylated at N-8 position.