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Paper | Regular issue | Vol 34, No. 10, 1992, pp.1965-1972
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6136
Isolation of the Intermediates and Improved Synthesis of Pyrido[1’,2’:1,2]imidazo[4,5-b]pyrazines and -quinoxalines

Akira Katoh,* Shuhei Ueda, Junko Ohkanda, Mutsumi Hirota, Hiroshi Komine, and Keiryo Mitsuhashi

*Department of Industrial Chemistry, Faculty of Engineering, Seikei University, Musashino-shi, Tokyo 180, Japan


2-(Pyrid-2’-yl)amino-3-chloro-5,6-dicyanopyrazines (IIa, IId, and IIe) and 2-(pyrid-2’-yl)amino-3-chloro-6-nitroquinoxalines (Va-c) were isolated for the first time in the course of the reaction of 2,3-dichloro-5,6-dicyanopyrazine (I) and 2,3-dichloro-6-nitroquinoxaline (IVa), respectively, with 2-aminopyridines. Furthermore, the yield of pyrido[1’,2’:1,2]imidazo[4,5-b]quinoxalines was remarkably improved due to the modification of the reaction conditions.