Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 34, No. 12, 1992, pp.2301-2311
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6121
Synthesis and Biological Activity of Novel N-1-Aryl-6-fluoro-5-methyl 1,8-Naphthyridine-3-carboxylic Acids

Jean-Pierre Jacquet,* Daniel Bouzard, Pierre Di Cesare, Nicolas Dolnic, Massoud Massoudi, and Philippe Remuzon

*Bristol-Myers Squibb Pharmaceutical Research Institute, B.P. 62, 77422 Marne-La-Vallée Cedex 2, France


A series of 5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acids was prepared in which the N-1 position was substituted by various aryl groups. Seven compounds showd excellent in vitro antibacterial activity against Gram-positive and Gram-negative strains.