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Paper | Regular issue | Vol 34, No. 9, 1992, pp.1847-1856
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6114
Synthesis of OPC-15161

Hao Jing, Kazunori Murakami, Yutaka Aoyagi, and Akihiro Ohta*

*Tokyo College of Pharmacy, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan

Abstract

OPC-15161 (1), an inhibitor of superoxide anion generation by guinea pig macrophages, was synthesized from 5-chloro-3-isobutyl-6-methylpyrazine in several steps.