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Paper | Regular issue | Vol 34, No. 10, 1992, pp.1905-1916
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6101
A Synthesis of 1,2,3,4-Tetrahydro-1,6-naphthyridines

Pedro J. Victory,* Jordi Teixidó, and José I. Borrell

*CETS Institut Químic de Sarrià, (Universitat Ramon Llull), Departament de Química Orgànica, E-08017 Barcelona, Spain


8-Cyano-3,4-dihydro-1,6-naphthyridin-2(1H)-ones were obtained by nucleophilic substitution of the methoxyl group of 5-cyano-3,4-dihydro-6-methoxy-2(1H)-pyridones (5a-d) by malononitrile or cyanoacetamide followed by cyclization in acidic or basic medium.