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Paper | Regular issue | Vol 34, No. 9, 1992, pp.1759-1771
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6085
The Synthesis of Pyrrolo[1,2-a]pyrazin-1(2H)-ones and Pyrrolo[1,2-b]pyridazin-6(5H)-ones

Derek McHattie,* Robert Buchan, Martin Fraser, and Paul V. S. Kong Thoo Lin

*Department of Applied Science, The Robert Gordon Institute of Technology, St Andrew’s Street, Aberdeen AB1 1HG, Scotland

Abstract

The pyrrolo[1,2-a]pyrazin-1(2H)-ones (10), (11), (12) and (13) and the pyrrolo[1,2-b]pyridazin-6(5H)-one (18) were prepared either a) directly by Chichibabin quaternisation-cyclisation of the corresponding methoxymethylpyrazine or pyridazine or b) by hydrogen halide hydrolysis of methoxypyrrolo[1,2-a]pyrazines and methoxypyrrolo[1,2-b]pyridazines. Protonation studies and some reactivity of the systems are discussed.