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Paper | Regular issue | Vol 34, No. 9, 1992, pp.1729-1736
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6061
The Synthesis of Fluorine-containing Aza-macrocyclic Compounds

Zhan-Ting Li, Yong-Da Lin, and Ching-Sung Chi*

*Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Road, Shanghai 200032, China


Four aza-macrocyclic compounds were synthesized by reactions of phthalaldehydes and phthaloyl chlorides with N,N’-di(2-aminomethyl-3-fluorophenyl)ethylenediamine (8) and their structures were identified. The nucleophilic substitution reaction of 2,6-difluorobenzonitrile (1) was discussed.