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Paper | Regular issue | Vol 34, No. 7, 1992, pp.1343-1352
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6020
Synthesis and Configurational Study of 2-Arylmorpholines

Raymond Houssin, Marie-Pierre Vaccher, Jean-Pierre Hénichart, and Daniel Lesieur*

*Institut de Chimie Pharmaceutique, Université de Lille II, B.P. 83, 59006 Lille, France


The synthesis of various 2-(2,3-dihydro-3-methyl-2-oxobenz[d]oxazol-6-yl)morpholines is reported. It has been demonstrated that 2-hydroxymorpholines or β-hydroxyethylaminomethyl ketones are formed as intermediates as assessed by ir, uv, 1H and 13C nmr analyses. The configuration of the title compounds was also established and corresponds to an equatorial orientation of the aromatic substituent which is considered as essential for an adrenergic activity.