Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 34, No. 6, 1992, pp.1075-1083
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6005
Giganenin, a Highly Potent Monotetrahydrofuran Acetogenin and 4-Deoxygigantecin from Goniothalamus giganteus

Xin-Ping Fang, Jon E. Anderson, David L. Smith, Karl V. Wood, and Jerry L. McLaughlin*

*Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, U.S.A.

Abstract

Giganenin, a novel monotetrahydrofuran acetogenin with a double bond along the hydrocarbon chain, and 4-deoxygigantecin, a new nonadjacent bistetrahydrofuran acetogenin, have been isolated from the bark of Goniothalamus giganteus (Annonaceae) by the use of brine shrimp lethality for bioactivity-directed fractionation. The structures were elucidated based on spectral and chemical methods. Giganenin, which shows selective and highly potent cytotoxicities to human tumor cells in culture (ED50 values as low as 5.80 x 10-8 μg/ml) and toxicity to brine shrimp, is the most cytotoxic of the monotetrahydrofuran acetogenins reported thus far. 4-Deoxygigantecin is also cytotoxic to human tumor cells and toxic to brine shrimp.