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Communication | Regular issue | Vol 34, No. 5, 1992, pp.875-879
Published online, 1st January, 1970
DOI: 10.3987/COM-92-5985
Synthesis of 5-Alkyl Substituted Uracil Derivatives from Barbituric Acid

Ilaria Candiani, Walter Cabri, Angelo Bedeschi,* Tiziano Martinengo, and Sergio Penco

*Farmitalia Carlo Erba-R&D, Via dei Gracchi, 35, 20146 Milan, Italy


A new two step synthesis of 5-alkyluracil derivatives from barbituric acids is described. Regioselective mono O-mesylation of barbituric acids, followed by desulfonylation under reductive conditions, afforded uracils in high overall yield. The reductive desulfonylation step is also discussed.