Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 34, No. 5, 1992, pp.875-879
Published online, 1st January, 1970
DOI: 10.3987/COM-92-5985
Synthesis of 5-Alkyl Substituted Uracil Derivatives from Barbituric Acid

Ilaria Candiani, Walter Cabri, Angelo Bedeschi,* Tiziano Martinengo, and Sergio Penco

*Farmitalia Carlo Erba-R&D, Via dei Gracchi, 35, 20146 Milan, Italy

Abstract

A new two step synthesis of 5-alkyluracil derivatives from barbituric acids is described. Regioselective mono O-mesylation of barbituric acids, followed by desulfonylation under reductive conditions, afforded uracils in high overall yield. The reductive desulfonylation step is also discussed.