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Communication | Special issue | Vol 33, No. 2, 1992, pp.545-548
Published online, 1st January, 1970
DOI: 10.3987/COM-91-S98
Conversion of the Synthetic Precursor for Ipecac and Corynanthe Alkaloids into Synthetic Intermediates of Quinine Alkaloids and (±)-Dihydroantirhine

Nobuaki Taniguchi, Masataka Ihara, and Keiichiro Fukumoto*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


The epimeric mixture of the trans-substituted tetrahydropyran derivatives (1) was transformed to the cis-substituted lactone (6), which was converted into the piperidine (3), the synthetic intermediate of dihydrocinchonine (5a) and dihydrocinchonidine (5b) , and the synthetic precursor (11) of (±)-dihydroantirhine (4) .