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Communication | Special issue | Vol 33, No. 2, 1992, pp.529-531
Published online, 1st January, 1970
DOI: 10.3987/COM-91-S90
Synthesis of a Dodecadeoxyribooligonucleotide Containing a 3'-Thio Analogue of Thymidine Photodimer

Tetsuya Murata, Shogenori Iwai, and Eiko Ohtsuka*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan


3’-Thio analogue of thymidine 3’-phosphate (Tsp) was incorporated into a dodecadeoxyribonucleotide at the 5’-side of dithymidylate to yield dGCACGTspTGCACG. The oligonucleotide was synthesized by the phosphoramidite method and converted to the cis -syn thymine dimer derivative by irradiation with uv, then isolated by high performance liquid chromatography.