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Paper | Regular issue | Vol 34, No. 4, 1992, pp.791-798
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5969
Facile Synthetic Methods for 3- and 5-Trifluoromethyl-4-trifluoroacetylpyrazoles and Their Conversion into Pyrazole-4-carboxylic Acids

Etsuji Okada, Ryoichi Masuda, and Masaru Hojo*

*Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe 657, Japan

Abstract

3- and 5-Trifluoromethyl-4-trifluoroacetylpyrazoles (4 and 5) were easily synthesized in excellent yields by reaction of β,β-bis(trifluoroacetyl)vinyl ethers 1, sulfides 2, and -amines 3 with hydrazines. Hydrolysis of these compounds (4 and 5) with aqueous potassium hydroxide gave the corresponding pyrazole-4-carboxylic acids (6 and 7) in high yields.