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Paper | Regular issue | Vol 34, No. 3, 1992, pp.549-559
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5944
Diorganotin Derivatives of 2,6-Dihydroxymethylpyridine and of 3-(N-Pyrrolidino)-1,2-propanediol: Synthesis, Characterization and in vitro Antitumor Activity

Marcel Gielen,* Mohammed Bouâlam, Monique Biesemans, Bernard Mahieu, and Rudolph Willem

*Free University of Brussels, Departement of General and Organic Chemistry, Faculty of Engineering, Room 8G512, Pleinlaan 2, B-1050 Brussels, Belgium

Abstract

Three diorganotin(IV) derivatives of 2,6-dihydroxymethylpyridine and 3-(N-pyrrolidino)-1,2-propanediol have been synthesized and characterized by Mössbauer spectroscopy, mass spectrometry and by 1H, 13C and 119Sn nmr. Their activities in vitro against two human tumor cell lines, MCF-7 and WiDr, are compared to those of cis-platin and doxorubicin.