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Paper | Regular issue | Vol 34, No. 2, 1992, pp.363-367
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5933
Synthesis of (2S,4S)-2-Hydroxy-4-hydroxymethyl-4-butanolide, a Hunger Substance

Katsuya Matsumoto,* Takashi Ebata,* Koshi Koseki, Hiroshi Kawakami, Koji Okano, and Hajime Matsushita

*Life Science Research Laboratory, Japan Tobacco Inc., 6-2 Umegaoka, Midori-ku, Yokohama, Kanagawa 227, Japan


(2S,4S)-2-Hydroxy-4-hydroxymethyl-4-butanolide (1a), which is a hunger substance, was synthesized stereoselectively starting from D-γ-ribono-1,4-lactone (2).