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Communication | Regular issue | Vol 34, No. 2, 1992, pp.241-245
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5925
Preparation of (6R)- and (6S)-(1R,4R)-6-Methyl-2-(p-toluenesulfonyl)-5-phenylmethyl-2,5-diazabicyclo[2.2.1]heptanes, Intermediates in a Synthesis of New Quinolones

Philippe Remuzon,* Daniel Bouzard, Christian Dussy, Jean-Pierre Jacquet, and Massoud Massoudi

*Bristol-Myers Squibb Pharmaceutical Research Institute, BP 62, Lognes, 77422 Marne-la-Vallée Cedex 2, France


An efficient chiral synthesis of both diastereoisomers (2a) and (2b) was performed using trans-4-hydroxy-L-proline as starting material. These bridged piperazines were used in the preparation of quinolones.