Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 34, No. 2, 1992, pp.241-245
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5925
Preparation of (6R)- and (6S)-(1R,4R)-6-Methyl-2-(p-toluenesulfonyl)-5-phenylmethyl-2,5-diazabicyclo[2.2.1]heptanes, Intermediates in a Synthesis of New Quinolones

Philippe Remuzon,* Daniel Bouzard, Christian Dussy, Jean-Pierre Jacquet, and Massoud Massoudi

*Bristol-Myers Squibb Pharmaceutical Research Institute, BP 62, Lognes, 77422 Marne-la-Vallée Cedex 2, France

Abstract

An efficient chiral synthesis of both diastereoisomers (2a) and (2b) was performed using trans-4-hydroxy-L-proline as starting material. These bridged piperazines were used in the preparation of quinolones.