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Paper | Regular issue | Vol 32, No. 12, 1991, pp.2407-2415
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5867
Synthesis of Halohydroxypyrazines and Their Synthetic Utility

Yutaka Aoyagi, Takako Fujiwara, and Akihiro Ohta*

*Tokyo College of Pharmacy, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Treatment of hydroxypyrazines with N-halosuccinimide (NXS; X = Cl, Br, I) in N,N-dimethylformamide (DMF) at room temperature afforded halohydroxypyrazines in good yields. Their synthetic utility was examined.