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Paper | Regular issue | Vol 34, No. 3, 1992, pp.457-464
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5840
Studies on 2-Substituted Methylazoles: Novel Synthesis of 6-(N-Piperidinyl) and 6-(N-Morpholinyl)-1,4-dihydropyridine Derivatives Incorporating Benzimidazole Moiety with Anticipated Biological Activity

Galal A. M. Nawwar,* Hussein F. Zohdi, Randa H. Swellem, and Soad A. Osman

*National Research Center, Dokki, Cairo, Egypt


The reaction of 2-(2-benzimidazolyl)acetonitrile with 3-(2-hydroxyaryl)propenones (2) in the presence of three equivalents of bases afforded the titled ring systems. When 2-(2-benzothiazolyl)acetonitrile was used instead of 2-(2-benzimidazolyl)acetonitrile the reaction afforded the 2-(benzopyran-3-yl)benzothiazole (9).