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Paper | Regular issue | Vol 32, No. 10, 1991, pp.1947-1953
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5819
Easy and Efficient SNAr Reactions on Halopyridines in Solvent Free Conditions

André Loupy,* Noelle Philippon, Philippe Pigeon, and Hervé Galons

*Laboratoire des Rèactions Sélective sur Supports, UA CNRS-478, Bâtiment 410, Universite Paris-Sud 91405 Orsay Cedex, France

Abstract

Solid-liquid phase transfer catalysis (PTC) without added solvent efficiently promotes SNAr reactions on halopyridines with a variety of anionic nucleophiles generated in situ. This methodology gives access to substituted pyridines in very simplified conditions depending on halide nature. Mechanistic investigations are proposed.