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Paper | Regular issue | Vol 32, No. 9, 1991, pp.1813-1820
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5813
Synthesis of 2,5-Disubstituted 3-(4-Chlorobenzoyl)-2,3-dihydro-2-methyl-1,3,4-thiadiazole Derivatives

Kouhei Toyooka,* Yoshiyuki Takeuchi, Masayuki Shibuya, and Seiju Kubota

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan

Abstract

2-Substituted 3-(4-chlorobenzoyl)-2,3-dihydro-5-methylthio-1,3,4-thiadiazoles (3) were used as key intermediates to prepare 2,5-disubstituted 3-(4-chlorobenzoyl)-2,3-dihydro-1,3,4-thiadiazoles (4) and (7).