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Paper | Regular issue | Vol 32, No. 9, 1991, pp.1777-1780
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5792
Use of Mercaptoacetaldehydes Dimer in a Novel Thienoannelation Sequence. A Short Synthesis of Ticlopidine

Owen W. Gooding* and Colin C. Beard

*Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304, U.S.A.


A short synthesis of ticlopidine (1) was achieved by condensation of mercaptoacetaldehyde dimer (2) with piperidone (3b) in the presence of lithium diisopropylamide followed by dehydration.