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Communication | Regular issue | Vol 32, No. 10, 1991, pp.1869-1873
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5780
Nucleophilic Addition to Homochiral N-Acylisoquinolinium Salts. Asymmetric Synthesis of (+)-Carnegine

Daniel L. Comins* and Mohamed M. Badawi

*Department of Chemistry, North Carolina State Univesity, Raleigh, NC 27695-8204, U.S.A.


The asymmetric addition of methyl nucleophiles to homochiral N-acylisoquinolinium salts was studied and utilized in a synthesis of the tetrahydroisoquinoline alklaoid, (+)-carnegine.