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Communication | Regular issue | Vol 32, No. 8, 1991, pp.1471-1482
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5778
Secondary Metabolites by Chemical Screening 14. Transformation of Elaiophylin in subunits of Naturally Occurring Acid Ionophores: Synthesis, Anticoccidial Activity and Studies Concerning the Ionophoric Properties

Peter Hammann,* Gerhard Kretzschmar, Robert Klein, Wolfgang Raether, Maria Kajtár-Peredy, Achim Kröger, and Frank Ditzel

*Entwicklungsgruppe Synthese und SBU Antiinfektiva, Allgemeine Pharma Forschung, Hoechst AG, Postfach 800320, D-65926 Frankfurt, Main 80, Germany


The synthesis of the polyether subunits (8 - 11), starting from elaiophylin (1), as well as their biological properties, nmr spectra and conformational studies were described and discussed. Based upon the missing ability of potassium transport it was deduced that compounds (8 -11) were new laed structures concerning their anticoccidial activity.