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Paper | Regular issue | Vol 32, No. 8, 1991, pp.1537-1545
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5751
An Unusual Condensation of Pyrimidinones: Synthesis of Bipyrimidinones and Bipyrimidinylmethane

Maurizio Botta,* Raffaele Saladino, Augusto Gambacorta, and Rosario Nicoletti*

*Dipartimento Farmaco Chimico Tecnologico, Banchi di Sotto 55, Università degli Studi, 53100 Siena, Italy


An unusual condensation of pyrimidinones (2), (3), and (12) in the presence of lithiated furan derivatives or LiHMDS lead to the formation of 7, 8, and 13. In the case of the self condensation of 3, a novel acyloin reaction is invoked to explain the formation of product (8) where the substrate acts as the catalyst in the reaction.