Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 32, No. 5, 1991, pp.1003-1012
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5720
Fused Imidazophenothiazines: Studies on the Bernthsen Thionation of 1-Methyl-6-(p-tolylamino)benzimidazole and 2-Methyl-1-phenylbenezimidazole

Pilar López-Alvarado, Carmen Avendaño,* and J. Carlos Menéndez

*Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain


Thionation of 1-methyl-6-(p-tolylamino)benzimidazole (obtained from 1-methyl-6-aminobenzomidazole and p-tolyllead triacetate) afforded a 7:3 mixture of two isomeric imidazophenothiazines, by inclusion of sulphur into the C7 and C2 ’ or C5 and C2’ positions, respectively. The capability of 1-arylbenzimidazoles to cyclize to a fused imidazophenothiazine was also shown. These results are discussed in comparison to those previously obtained on 2-methyl-1-phenyl-5-phenylaminobenzimidazole, a more complex system where both diarylamine units are present.