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Paper | Regular issue | Vol 32, No. 4, 1991, pp.735-748
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5684
Efficient Alkylation and Acylation of Pyrazine 1-Oxides

Yutaka Aoyagi, Atsushi Maeda, Masami Inoue, Mitsuhiro Shiraishi, Yuki Sakakibara, Yuko Fukui, and Akihiro Ohta,* Kenzo Kajii, and Yoshio Kodama

*Tokyo College of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

Reactions of pyrazine 1-oxides with electrophiles in the presence of LTMP (lithium 2,2,6,6-tetramethylpiperidine) and TMEDA (N,N,N ’,N ’-tetramethylethylenediamine) afforded 2-alkyl- and 2-acylpyrazine 1-oxides in good yields, and the products could be deoxygenated with PBr3 and Raney Ni successfully.