Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 32, No. 4, 1991, pp.735-748
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5684
Efficient Alkylation and Acylation of Pyrazine 1-Oxides

Yutaka Aoyagi, Atsushi Maeda, Masami Inoue, Mitsuhiro Shiraishi, Yuki Sakakibara, Yuko Fukui, and Akihiro Ohta,* Kenzo Kajii, and Yoshio Kodama

*Tokyo College of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Reactions of pyrazine 1-oxides with electrophiles in the presence of LTMP (lithium 2,2,6,6-tetramethylpiperidine) and TMEDA (N,N,N ’,N ’-tetramethylethylenediamine) afforded 2-alkyl- and 2-acylpyrazine 1-oxides in good yields, and the products could be deoxygenated with PBr3 and Raney Ni successfully.