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Communication | Regular issue | Vol 32, No. 3, 1991, pp.431-436
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5656
Synthetic Studies on Aplysiatoxin. Intramolecular Ester Formation from 3-Acetoxyfuran Derivative via Oxidative Ring Opening Reaction

Kunisuke Okada,* Masanori Mizuno, Hidetsugu Sasaki, Kenji Sugiura, Hideo Tanino, Hisae Kakoi, and Shoji Inoue

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan

Abstract

Two steps synthesis of 3-acetoxyfuran derivative (4) from acetylene derivative (3) and the conversion 4 to (3R,4R)-3,4-dihydroxypentanoic acid derivative (5) are described.