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Paper | Regular issue | Vol 32, No. 4, 1991, pp.693-701
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5638
Synthesis of Two New Thiazole-containing Oligopeptides as Potential DNA Minor Groove Binding Analogs of Netropsin

Bertrand Plouvier, Christian Bailly, Raymond Houssin, and Jean-Pierre Hénichart*

*Institut de Chimie Pharmaceutiqe, Université de Lille 2, 3, rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France


On the basis of previous studies on synthetic models related to the antibiotic agents Netropsin and Distamycin-A, the design and synthesis of two potential DNA minor groove ligands are described. Methia-Nt and Isothia-Nt were prepared by liquid-phase peptidic synthesis from the key compounds ethyl 2-amino-5-methylthiazole-4-carboxylate (1) and ethyl 2-aminothiazole-5-carboxylate (8) respectively.