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Paper | Regular issue | Vol 32, No. 5, 1991, pp.907-914
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5636
Synthesis of 1,3-Diaryl-1,3-dihydro-4,5-dioxo-2-thioxofuro[2,3-d]pyrimidines and 1,3-Diaryl-1,3-dihydro-2-thioxo-5-(thiazol-4-l)-2H,5H-pyrimidine-4,6-diones

Vinod Kumar Ahluwalia,* Rashmi Sharma, Chandra Has Khanduri, M. Kaur, and Charu Gupta

*Department of Chemistry, University of Delhi, Delhi-110 007, India


The reaction of thiobarbituric acids with chloroacetyl chloride in presence of triethylamine afforded 5-chloroacetyl derivatives which on cyclisation with ethanolic sodium acetate gave the corresponding furo[2,3-d]pyrimidines. Further the 5-chloroacetyl derivative on reaction with ammonium dithiocarbamate and thioacetamide gave 1,3-diaryl-1,3-dihydro-2-thioxo-5-(thiazol-4-yl)-2H,5H-pyrimidine-4,6-diones.