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Paper | Regular issue | Vol 32, No. 1, 1991, pp.85-92
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5619
Synthesis of the Parent Systems of Dipyrrolo[1,2-a:2’,1’-c]pyrazine and of Dipyrrolo[1,2-a:2’,1’-c]quinoxaline

Anna Berlin, Stefano Martina, Giorgio Pagani,* Gilberto Schiavon, and Gianni Zotti

*Dipartimento di Chimica Organica e Industriale, Università digli Studi di Milano, via Golgi 19, I-20133 Milano, Italy


A synthesis of the title compounds is described starting from 2,3-dimethylpyrazine and 2,3-dimethylquinoxaline, respectively. The two pyrrole rings are formed in two subsequent steps by condensation of the methyl groups of the starting azines with the carbonyl groups of the ethyl pyruvate moiety linked to the ring nitrogen atoms. Deuterium exchange reactions of dipyrrolo [1,2-a:2’,1’-c]pyrazine are also reported.