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Communication | Regular issue | Vol 31, No. 12, 1990, pp.2125-2129
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5618
Antimalarial Artemisinin Analogs: Synthesis of 2,3-Desethano-12-deoxoartemisinin-related Compounds

Yasuhiro Imakura,* Katsutoshi Hachiya, Tomomi Ikemoto, Shigeru Kobayashi, Shinsuke Yamashita, Jinsaku Sakakibara, Forrest T. Smith, and Kuo-Hsiung Lee

*Faculty of Sciences, Naruto University of Education, Takashima, Naruto-shi, Tokushima 772- , Japan

Abstract

2,3-desethano-12-deoxoartemisinin-related compounds ((+)-16a) and ((-)-16b) have been synthesized from R-(+)-citronellal (7) by a stereoselective manner, which is applied to the synthesis of various novel antimalarial artemisinin analogs.