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Paper | Regular issue | Vol 32, No. 8, 1991, pp.1505-1515
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5595
Synthesis and Beta-Lactamase Inhibitory Activity of 2,2-Bis(monosubstituted) Methylpenicillin Sulfones

Samarendra N. Maiti,* Paul Spevak, Rebecca Wong, Narender A. V. Reddy, Ronald G. Micetich, and Kazuo Ogawa

*SynPhar Laboratories Inc., 4290-91A Street, Edmonton, Alberta, T6E 5V2, Canada


A series of 2,2-bis(monosubstituted) methylpenicillin sulfones were prepared from 6,6-dibromopenicillanate by a double sulfoxide rearrangement. β-Lactamase inhibitory activity of 2,2-bis(chloromethyl)penicillanic acid sulfone was studied and its activity was compared with YTR-830.